Three adults with acute lymphoblastic leukemia and dic(7;9)(p11.2;p11)
Received 27 June 2005; received in revised form 29 July 2005; accepted 9 August 2005.
Abstract
We report the cases of three adults with acute lymphoblastic leukemia (ALL) who had a dic(7;9)(p11.2;p11) on the diagnostic bone marrow cytogenetic analysis. All three were males with B-ALL (aged 25, 38, and 48 years) who at presentation had 90–100% replacement of marrow with lymphoblasts. One patient died 23 months post induction therapy, which was 9 months post allogeneic stem cell transplantation (SCT); as of writing, the other two patients were in remission and well, one of them at 4 years after SCT and the other at 7.5 years without SCT. To our knowledge, these cases are the first reported in adult ALL with dic(7;9) and demonstrate a consistent phenotype, with good initial response to therapy but variable long-term outcome.
aDepartment of Cytogenetics, Royal Alexandra Hospital for Children, Locked Bag 4001, Westmead, NSW 2145, Australia
bDepartment of Haematology and Bone Marrow Transplantation, Westmead Hospital, Westmead, NSW, Australia
cDepartment of Haematology, Royal Perth Hospital, Perth, WA, Australia
dDepartment of Cytogenetics, St. Vincent's Hospital, Melbourne, VIC, Australia
ABSTRACT