Abstract
We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal
junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses
as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas
by means of 32k high-resolution array-based comparative genomic hybridization and
27k oligo gene expression arrays, and putative target genes were validated in an extended
series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction
showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15,
13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34
characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal
junction, with upregulation in one quarter of the tumors. Gains/losses and gene expression
profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal
junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that
molecular diagnostics and targeted therapies can be applied to adenocarcinomas of
the distal esophagus and gastroesophageal junction alike.
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Article info
Publication history
Accepted:
March 30,
2010
Received in revised form:
March 3,
2010
Received:
November 2,
2009
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
