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Clonal chromosome aberrations secondary to chromosome instability in an elastofibroma

        Elastofibromas are slow growing fibroblastic proliferations usually considered to be due to a reactive rather than neoplastic process [
        • Enzinger F.M.
        • Weiss S.W.
        Benign fibrous tissue tumors.
        ]. They occur mainly in elderly patients typically at a site between the scapula and chest wall. Treatment by surgical excision is invariably successful and recurrence is rare. While there is some controversy as to whether such lesions are true neoplasms they have attracted little attention by genetic investigators. However, Vanni et al. [
        • Vanni R.
        • Marras S.
        • Faa G.
        • Uccheddu A.
        • Dal Cin P.
        • Sciot R.
        • Samson I.
        • van den Berghe H.
        Chromosome instability in elastofibroma.
        ] recently reported the cytogenetic findings of three elastofibromas, surgically excised from 2 patients, in which they described a picture of “chromosome instability” amidst an essentially normal karyotype. We too, have recently had occasion to cytogenetically investigate a soft tissue tumor histopathologically defined as an elastofibroma.
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