Abstract
The incidence of acute myelogenous leukemia (AML) in patients with constitutional
trisomy 21 is estimated to be 1 in 300; it is usually seen before age four. Clinical
and epidemiological data confirm the improved life expectancy of patients with Down
syndrome and their increased susceptibility to the development of leukemia, among
other cancers. The most frequent subtype of AML associated with Down syndrome is acute
megakaryoblastic leukemia (FAB: M7). The description of acute promyelocytic leukemia
(APL) in adult patients with Down syndrome is exceedingly rare. Herein, we describe
the unusual presentation, treatment, results, and clinical course of an adult patient
with APL and constitutional trisomy 21 and provide a brief review of the literature.
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Article info
Publication history
Accepted:
August 10,
2005
Received in revised form:
July 14,
2005
Received:
March 15,
2005
Identification
Copyright
© 2006 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
