Advertisement

A t(12;17) in an extraorbital giant cell angiofibroma

      Abstract

      We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass. ©2006 Elsevier Inc. All rights reserved.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Cancer Genetics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Dei Tos A.P.
        • Seregard S.
        • Calonje E.
        • Chan J.K.
        • Fletcher C.D.
        Giant cell angiofibroma. A distinctive orbital tumor in adults.
        Am J Surg Pathol. 1995; 19: 1286-1293
        • Guillou L.
        • Gebhard S.
        • Coindre J.M.
        Orbital and extraorbital giant cell angiofibroma: a giant cell–rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept.
        Am J Surg Pathol. 2000; 24: 971-979
        • Keyserling H.
        • Peterson K.
        • Camacho D.
        • Castillo M.
        Giant cell angiofibroma of the orbit.
        AJNR Am J Neuroradiol. 2004; 25: 1266-1268
        • Yazici B.
        • Setzen G.
        • Meyer D.R.
        • Williams E.F.
        • McKenna B.J.
        Giant cell angiofibroma of the nasolacrimal duct.
        Ophthal Plast Reconstr Surg. 2001; 17: 202-206
        • Sigel J.E.
        • Fisher C.
        • Vogt D.
        • Goldblum J.R.
        Giant cell angiofibroma of the inguinal region.
        Ann Diagn Pathol. 2000; 4: 240-244
        • Thomas R.
        • Banerjee S.S.
        • Eyden B.P.
        • Shanks J.H.
        • Bisset D.L.
        • Hunt R.
        • Byers R.J.
        • Oogarah P.
        • Harris M.
        A study of four cases of extra-orbital giant cell angiofibroma with documentation of some unusual features.
        Histopathology. 2001; 39: 390-396
        • Sandberg A.A.
        • Bridge J.A.
        Updates on the cytogenetics and molecular genetics of bone and soft-tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastoma.
        Cancer Genet Cytogenet. 2003; 140: 1-12
        • Sonobe H.
        • Iwata J.
        • Komatsu T.
        • Fukushima A.
        • Hayashi N.
        • Moriki T.
        • Shimizu K.
        • Ohtsuki Y.
        A giant cell angiofibroma involving 6q.
        Cancer Genet Cytogenet. 2000; 116: 47-49
        • Debiec-Rychter M.
        • de Wever I.
        • Hagemeijer A.
        • Sciot R.
        Is 4q13 a recurring breakpoint in solitary fibrous tumors?.
        Cancer Genet Cytogenet. 2001; 131: 69-73
        • Tanahashi N.
        • Suzuki M.
        • Fujiwara T.
        • Takahashi E.
        • Shimbara N.
        • Chung C.H.
        • Tanaka K.
        Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases.
        Biochem Biophys Res Commun. 1998; 243: 229-232