Abstract
In the interpretation of the varied and complex cytogenetic counts obtained in analysis
of bone marrow (BM) samples for leukemia, loss or gain of certain chromosomes may
or may not be significant for prognosis. Loss of the Y chromosome in elderly males
is a benign finding. Trisomy 15 is rare and may represent another age-related abnormality,
particularly in males, together with −Y. We reviewed 3,242 routine referrals sent
to our laboratory for BM cytogenetics, over a period of 34 months. We detected 5 cases
with uncomplicated trisomy 15, 3 in males and 2 in females. Three of these patients
had the diagnosis of myelodysplastic syndrome (MDS). All 3 males showed a −Y cell
line, although the 2 females did not have an X chromosome loss. All 5 patients were
alive and well at times varying from 12 months to 4 years post-diagnosis. In the further
analysis of our referral cohort, there were 62 males with loss of the Y chromosome
as the sole abnormality, and of these 47 (76%), were referred with myeloid disease.
The frequency of trisomy 15 in our laboratory was 1/475 referrals, but 1/292 in successful
cultures from new patients. This is the first report providing frequency data for
trisomy 15. Further data with longer term follow-up is required to establish the significance
of trisomy 15 in elderly leukemic patients.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Cancer GeneticsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Interpretation of chromosome counts made on bone marrow cells.Lancet i:. 1960; 160–163
- Distribution of human chromosome counts in relation to age.Nature. 1961; 191: 1178-1180
- Aneuploidy in culture.J Ment Defic Res. 1980; 24: 159-165
- The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.Am J Hum Genet. 1990; 46: 1101-1111
- Loss of the Y chromosome from normal and neoplastic bone marrow.Genes Chromosom Cancer. 1992; 5: 83-88
- Trisomy 15 associated with loss of the Y chromosome in bone marrow.Cancer Genet Cytogenet. 1998; 105: 20-23
- Fluorodeoxyuridine synchronisation of bone marrow cultures.Cancer Genet Cell Genet. 1983; 8: 123-132
- A case of chronic myelomonocytic leukemia with isochromosome 14q.Cancer Genet Cytogenet. 1998; 101: 134-137
- Basic techniques for the preparation and analysis of chromosomes from bone marrow and leukaemic blood.in: Rooney D.E Czepulkowski B.H Human Cytogenetics A Practical Approach, Vol. II. Malignancy and Acquired Abnormalities. 2nd Ed. IRL Press at Oxford University Press, New York1992: 1-19
- How does interferon exert its cell growth inhibitory effect?.Eur J Haematol. 1997; 59: 129-135
- Chromosome abnormalities in the myeloproliferative disorders.Semin Oncol. 1995; 22: 341-354
- Loss of the Y chromosome in acute myelogenous leukemia.Cancer Genet Cytogenet. 1985; 17: 269-278
- Cytogenetic abnormalities in primary myelodysplastic syndrome are highly predictive of outcome after allogeneic bone marrow transplantation.Blood. 1998; 92: 1910-1917
- International scoring system for evaluating prognosis in myelodysplastic syndromes.Blood. 1997; 89: 2079-2088
- Chromosome aneuploidy in Alzheimer's disease.Clin Genet. 1983; 24: 54-57
Article info
Publication history
Accepted:
March 1,
1999
Received:
December 21,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
