In the interpretation of the varied and complex cytogenetic counts obtained in analysis of bone marrow (BM) samples for leukemia, loss or gain of certain chromosomes may or may not be significant for prognosis. Loss of the Y chromosome in elderly males is a benign finding. Trisomy 15 is rare and may represent another age-related abnormality, particularly in males, together with −Y. We reviewed 3,242 routine referrals sent to our laboratory for BM cytogenetics, over a period of 34 months. We detected 5 cases with uncomplicated trisomy 15, 3 in males and 2 in females. Three of these patients had the diagnosis of myelodysplastic syndrome (MDS). All 3 males showed a −Y cell line, although the 2 females did not have an X chromosome loss. All 5 patients were alive and well at times varying from 12 months to 4 years post-diagnosis. In the further analysis of our referral cohort, there were 62 males with loss of the Y chromosome as the sole abnormality, and of these 47 (76%), were referred with myeloid disease. The frequency of trisomy 15 in our laboratory was 1/475 referrals, but 1/292 in successful cultures from new patients. This is the first report providing frequency data for trisomy 15. Further data with longer term follow-up is required to establish the significance of trisomy 15 in elderly leukemic patients.
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- Interpretation of chromosome counts made on bone marrow cells.Lancet i:. 1960; 160–163
- Distribution of human chromosome counts in relation to age.Nature. 1961; 191: 1178-1180
- Aneuploidy in culture.J Ment Defic Res. 1980; 24: 159-165
- The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.Am J Hum Genet. 1990; 46: 1101-1111
- Loss of the Y chromosome from normal and neoplastic bone marrow.Genes Chromosom Cancer. 1992; 5: 83-88
- Trisomy 15 associated with loss of the Y chromosome in bone marrow.Cancer Genet Cytogenet. 1998; 105: 20-23
- Fluorodeoxyuridine synchronisation of bone marrow cultures.Cancer Genet Cell Genet. 1983; 8: 123-132
- A case of chronic myelomonocytic leukemia with isochromosome 14q.Cancer Genet Cytogenet. 1998; 101: 134-137
- Basic techniques for the preparation and analysis of chromosomes from bone marrow and leukaemic blood.in: Rooney D.E Czepulkowski B.H Human Cytogenetics A Practical Approach, Vol. II. Malignancy and Acquired Abnormalities. 2nd Ed. IRL Press at Oxford University Press, New York1992: 1-19
- How does interferon exert its cell growth inhibitory effect?.Eur J Haematol. 1997; 59: 129-135
- Chromosome abnormalities in the myeloproliferative disorders.Semin Oncol. 1995; 22: 341-354
- Loss of the Y chromosome in acute myelogenous leukemia.Cancer Genet Cytogenet. 1985; 17: 269-278
- Cytogenetic abnormalities in primary myelodysplastic syndrome are highly predictive of outcome after allogeneic bone marrow transplantation.Blood. 1998; 92: 1910-1917
- International scoring system for evaluating prognosis in myelodysplastic syndromes.Blood. 1997; 89: 2079-2088
- Chromosome aneuploidy in Alzheimer's disease.Clin Genet. 1983; 24: 54-57
Accepted: March 1, 1999
Received: December 21, 1998
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.