Abstract
“Jumping” translocations (JT) are relatively rare and are associated with poor prognosis.
We report two male patients with childhood acute lymphoblastic leukemia (ALL) and
abnormal cell lines detected on bone marrow cytogenetics. Diagnostic marrow cytogenetics
were not available for either patient. In patient 1, approximately 11 years after
diagnosis, cytogenetics revealed a single translocation, t(1;2)(q23;q32), which was
followed by translocations t(1;22)(q23;p11) and t(1;1)(q23;q21.3). In patient 2, two
translocations were present together, t(1;6)(q23;p21.3) and t(1;11)(q23;q21), 12 years
after diagnosis. The unbalanced JTs in both patients resulted in partial trisomy for
(1)(q23→qter). Both died within 1–2 years after the appearance of the JT. Our patients
provide additional support for chromosome 1q preferential involvement in JTs, and
that their appearance is associated with a poor prognosis.
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Article info
Publication history
Accepted:
March 1,
1999
Received:
December 30,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
