Abstract
A novel Philadelphia (Ph) variant translocation, t(Y;9;22)(q12;q34;q11), was detected
in a 63-year-old man with a newly diagnosed chronic myeloid leukemia (CML). Reverse
transcription polymerase chain reaction (RT-PCR) analysis revealed a b3a2 fusion transcript.
Fluorescence in situ hybridization (FISH) utilizing library probes, subtelomeric cosmid
probes, and probes hybridizing to the ABL and BCR genes showed a reciprocal three-way translocation involving Yq12, 9q34, and 22q11,
and a BCR-ABL fusion signal on der(22). The subtelomeric Yq probe hybridizing centromerically to
the IL9 receptor gene and covering the centromeric portion of the SYBL1 gene was found to be translocated to der(9).
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Article info
Publication history
Accepted:
March 11,
1999
Received:
February 11,
1999
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
