A novel Philadelphia (Ph) variant translocation, t(Y;9;22)(q12;q34;q11), was detected in a 63-year-old man with a newly diagnosed chronic myeloid leukemia (CML). Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed a b3a2 fusion transcript. Fluorescence in situ hybridization (FISH) utilizing library probes, subtelomeric cosmid probes, and probes hybridizing to the ABL and BCR genes showed a reciprocal three-way translocation involving Yq12, 9q34, and 22q11, and a BCR-ABL fusion signal on der(22). The subtelomeric Yq probe hybridizing centromerically to the IL9 receptor gene and covering the centromeric portion of the SYBL1 gene was found to be translocated to der(9).
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Cancer Genetics
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Molecular insights into the Philadelphia translocation.Hematol Pathol. 1991; 5: 1-10
- Cancer Cytogenetics. Wiley-Liss, New York1995
- Successful use of the same slide for consecutive fluorescence in situ hybridization (FISH) experiments.Genes Chromosom Cancer. 1996; 16: 261-264
- A complete set of human telomeric probes and their clinical application.Nature Genet. 1996; 14: 86-89
- A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation.Nature Genet. 1996; 13: 227-229
ISCN (1995): An International System for Human Cytogenetic Nomenclature. F. Mitelman, ed. S. Karger, Basel.
- Complex chromosomal translocation in the Philadelphia chromosome leukemias. Serial translocations or a concerted genomic rearrangement?.Cancer Genet Cytogenet. 1991; 57: 143-151
- New variant Ph translocation in chronic myeloid leukemia.Cancer Genet Cytogenet. 1996; 87: 75-78
- Unusual Ph translocations in CML.Cancer Genet Cytogenet. 1985; 15: 199-207
- Y-chromosome structural rearrangement in Philadelphia chromosome-negative chronic myelogenous leukemia.N Engl J Med. 1980; 303: 53-54
- Karyotype evolution of Ph positive chronic myelogenous leukemia patients relapsed in advanced phases of the disease after allogeneic bone marrow transplantation.Cancer Genet Cytogenet. 1991; 57: 69-78
- Sequential development of peripheral T-cell lymphoma in the course of chronic myelogenous leukemia.Cancer. 1990; 66: 1198-1203
- A rosy future for heterochromatin.Proc Natl Acad Sci USA. 1994; 91: 5219-5221
Accepted: March 11, 1999
Received: February 11, 1999
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.