Abstract
Uterine leiomyomas are the most common benign tumor that arise from smooth muscle
cells of the myometrium. Little is known about the etiology and pathogenesis of this
tumor. To investigate the molecular pathogenesis of these tumors, we have conducted
an allelotype of 102 leiomyomas from 12 patients, using 67 fluorescently-tagged oligonucleotide
primers amplifying microsatellite loci covering all autosomes. No areas of the genome
showed frequent loss of heterozygosity (LOH); however, the highest rate of LOH (9%)
was observed on 7q, consistent with previous cytogenetic observations. Uterine leiomyomas
are sometimes multiple. In general, multiplicity of other types of neoplasm is associated
with genetic predisposition to the disease. Because multiple tumors were available
from each of the 12 patients studied, we looked for evidence of allele-specific LOH,
which might indicate the presence of an underlying predisposition gene. However, no
evidence for allele-specific LOH was detected, indicating that if cases of multiple
uterine leiomyoma are due to an underlying predisposition gene, it is unlikely to
be a recessive oncogene.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Cancer GeneticsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Dewhurst's Textbook of Obstetrics and Gynecology for Post-Graduates. 4th ed. Blackwell Scientific Publications, London1986: 726-733
- Green's Gynecology. Little Brown, and Co, Boston1990
- Effect of treatment with LHRH analogue Zoladex on binding of oestradiol, progesterone and epidermal growth factor to uterine fibromyomata.Horm Res. 1989; 32: 154-156
- Uterine leiomyoma cytogenetics II. Report of forty cases.Cancer Genet Cytogenet. 1991; 53: 247-256
- Chromosome analysis of 96 uterine leiomyomas.Cancer Genet Cytogenet. 1991; 55: 11-18
- Deletion of 7q22 in uterine leiomyomas. A cytogenetic review.Cancer Genet Cytogenet. 1993; 71: 1-6
- Comparison of chromosome aberrations in leiomyoma and leiomyosarcoma using FISH on archival tissues.Cancer Genet Cytogenet. 1994; 74: 19-24
- Translocations in 7q22 define a critical region in uterine leiomyomata.Cancer Genet Cytogenet. 1994; 77: 65-68
- A new cytogenetic subgroup in uterine leiomyoma is characterized by a deletion of the long arm of chromosome 3.Genes Chromosom Cancer. 1995; 13: 219-220
- HMGIC expressed in a uterine leiomyoma with a deletion of the long arm of chromosome 7 along with a 12q14–15 rearrangement but not in tumors showing del(7) as the sole cytogenetic abnormality.Cancer Genet Cytogenet. 1997; 96: 129-133
- Cytogenetic markers in selected gynecological malignancies.in: Wolman S.R. Sell S. Human Cytogenetic Cancer Markers. Humana Press, Totowa1997: 169-202
- Molecular cytogenetic characterization of del(7q) in two uterine leiomyoma-derived cell lines.Genes Chromosom Cancer. 1997; 18: 155-161
- Molecular and cytogenetic analysis of chromosome 7 in uterine leiomyomas.Genes Chromosom Cancer. 1995; 14: 51-55
- Two discrete regions of deletion at 7q in uterine leiomyomas.Genes Chromosom Cancer. 1997; 19: 156-160
- Molecular analysis of chromosome 7q21.3 in uterine leiomyoma.Cancer Genet Cytogenet. 1998; 100: 165-168
- Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and secondary nature of cytogenetic aberrations in the development of leiomyomata.Genes Chromosom Cancer. 1994; 11: 1-6
- The del(7q) subgroup in uterine leiomyomata.Cancer Genet Cytogenet. 1997; 98: 69-74
- Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization.Mol Carcinog. 1997; 19: 273-279
- The Cytogenetics of Bone and Soft Tissue Tumors. R. Landes Company, Austin1994
- Familial predisposition to uterine leiomyomas.Int J Gynaecol Obstet. 1995; 51: 127-131
- Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds.Cancer Res. 1994; 54: 6069-6072
- Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12–13.Oncogene. 1995; 10: 1673-1675
- Familial cylindromatosis (turban tumor syndrome) gene localised to chromosome 16q12–q13.Nature Genet. 1995; 11: 441-443
- The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumor suppressor gene involved in the development of cylindromas.Oncogene. 1996; 12: 1375-1377
- Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.Nature Genet. 1997; 15: 87-90
- The 1993–94 Genethon human genetic linkage map.Nature Genet. 1994; 7: 246-339
- A YAC contig map of the human genome.Nature. 1995; 377: 175-298
- Report of the sixth international workshop on human chromosome 3 mapping 1995.Cytogenet Cell Genet. 1996; 72: 255-270
- Report of the third international workshop on human chromosome 12 mapping 1995.Cytogenet Cell Genet. 1996; 73: 1-24
- Report of the fifth international workshop on human chromosome 21 mapping 1994.Cytogenet Cell Genet. 1995; 70: 147-182
- Report of the fourth international workshop on human chromosome 22 mapping 1994.Cytogenet Cell Genet. 1994; 67: 278-294
- Loss of heterozygosity in human primary prostate carcinomas.Cancer Res. 1994; 54 (a): 6370-6373
- C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.Proc Natl Acad Sci USA. 1994; 91 (b): 12155-12158
- Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1.Cancer Res. 1995; 55 (a): 1347-1350
- Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene.Oncogene. 1995; 11 (b): 359-363
- Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer.Genes Chromosom Cancer. 1997; 19: 1-5
Article info
Publication history
Accepted:
March 11,
1999
Received:
December 1,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
