Abstract
This paper presents the results of a cytogenetic analysis in an 11-year-old boy with
non-Hodgkin lymphoma. The investigation was performed on slides obtained from short-term
culture of lymph node cells. The analyses revealed an abnormal clone with loss of
the Y, gain of an X chromosome, t(3;22), trisomy 11, and three cytogenetically-related
subclones with jumping translocations involving 11q13 as the common breakpoint region.
This region is an unusual site of chromosome breakage in jumping translocations, and
has not been reported thus far. Contrary to most published reports, the jumping translocation
in our patient is associated with long survival.
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Article info
Publication history
Accepted:
March 10,
1999
Received:
July 31,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
