Abstract
Two patients with chromosome 16 inversion-associated translocation were studied with
conventional cytogenetic and fluorescence in situ hybridization (FISH) techniques.
The same chromosome 16 was involved in inversion and translocation in both patients.
The chromosome translocation breakpoint was located within the heterochromatin of
chromosome 16 but outside the alpha satellite domain in the t(10;16) of the first
patient, whereas it was outside the heterochromatin area in the second case with t(1;16).
These two types of rearrangements may be due to different mechanisms and illustrate
the possible difficulties in recognizing the chromosome 16 inversion without FISH
studies.
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References
- Variant translocations and inversion-associated translocations in acute myelomonocytic leukemia with eosinophilia.Genes Chromosom Cancer. 1995; 12: 58-62
- FISH identifies inv(16)(p13q22) masked by translocations in three cases of acute myeloid leukemia.Genes Chromosom Cancer. 1998; 22: 87-94
- Catalog of Chromosome Aberrations in Cancer. 5th ed. Wiley-Liss, New York1994
- Chromosome 16 and bone-marrow eosinophilia.N Engl J Med. 1983; 309: 1394
- Temporal variation in nucleolar organizer region expression in bone marrow cells of individuals with leukemia.Cancer Genet Cytogenet. 1988; 35: 109-117
- Chromosome 16 abnormalities associated with myeloid malignancies.Genes Chromosom Cancer. 1991; 3: 55-61
- Acute myelomonocytic leukemia with bone marrow eosinophilia and inv(Cancer Genet Cytogenet. 1991; 51: 235-238
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)(q32;q22). - Fusion between transcription factor CBFβ/PEPBP2β and a myosin heavy chain in acute myeloid leukemia.Science. 1993; 261: 1041-1044
- Detection of 16p deletions by FISH in patients with inv(16) or t(16;16) and acute myeloid leukemia (AML).Leukemia. 1997; 11: 964-970
)(p13q22), t(1;
)(q32;q22).Article info
Publication history
Accepted:
March 30,
1999
Received:
December 29,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
