Abstract
We describe a 41-year-old man with CD7-positive acute myeloid leukemia (AML-M0) with
trilineage-myelodysplasia. Chromosome analysis of the bone marrow cells showed 46,XY,t(2;4;12)(p21;q12;p13).
Cytological and clinical features of our case were quite similar to those of AML with
t(4;12)(q11∼12;p13). The karyotypic interpretation was confirmed by fluorescence in
situ hybridization (FISH) by using the whole-chromosome painting probes specific for
chromosomes 2, 4, and 12. FISH analysis with the use of the YAC 936e2 probe, which
covers the TEL gene, did not show the split signal, suggesting that a gene other than TEL was involved in the leukemogenesis of the present case. Our case with AML with t(2;4;12)(p21;q12;p13)
appears to be the first case of a variant type of AML with t(4;12)(q11∼12;p13).
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Article info
Publication history
Accepted:
March 30,
1999
Received:
December 29,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
