Chronic myelocytic leukemia (CML) is a clonal myeloproliferative disorder characterized
cytogenetically by the Philadelphia (Ph) chromosome, which arises from a reciprocal
translocation, (9;22)(q34;q11), and is characterized molecularly by the fusion of
parts of the C-ABL gene (9q34) with parts of the BCR gene (22q11), generating an abnormal BCR/ABL fusion gene [
1
,
2
]. In general, more than 85% of patients diagnosed as having CML are found to have
the Ph chromosome [
3
]. Variant forms of Ph translocations are seen in 5–10% of CML cases [
3
]. When CML progresses, additional chromosome aberrations are noted in 75–80% of the
cases, the most common ones being trisomy 8, an additional Ph, an i(17q), trisomy
19, trisomy 21, and loss of a sex chromosome [
3
].To read this article in full you will need to make a payment
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References
- A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining.Nature. 1973; 243: 290-292
- Cytogenetic and molecular analysis of the Ph translocation in chronic myeloid leukemia.Cancer Surv. 1984; 3: 515-529
- The Chromosomes in Human Cancer and Leukemia. ed 2. Elsevier Science, New York1990
- A breakpoint map of recurrent chromosomal rearrangements in human neoplasia.Nature Genet. 1997; 15: 417-474
- Some observations on fluorescence in situ hybridization evaluation of chronic myelocytic leukemia.Cancer Genet Cytogenet. 1997; 98: 1-3
ISCN (1995): An International System for Human Cytogenetic Nomenclature. F. Mitelman, ed. S. Karger, Basel.
Article info
Publication history
Accepted:
March 30,
1999
Received:
January 25,
1999
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
