Advertisement
Short communication| Volume 114, ISSUE 2, P156-158, October 15, 1999

Download started.

Ok

Instability of the Ph Chromosome in Chronic Myelocytic Leukemia

A Case Report
      Chronic myelocytic leukemia (CML) is a clonal myeloproliferative disorder characterized cytogenetically by the Philadelphia (Ph) chromosome, which arises from a reciprocal translocation, (9;22)(q34;q11), and is characterized molecularly by the fusion of parts of the C-ABL gene (9q34) with parts of the BCR gene (22q11), generating an abnormal BCR/ABL fusion gene [
      • Rowley J.D.
      A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining.
      ,
      • de Klein A.
      • Hagemeijer A.
      Cytogenetic and molecular analysis of the Ph translocation in chronic myeloid leukemia.
      ]. In general, more than 85% of patients diagnosed as having CML are found to have the Ph chromosome [
      • Sandberg A.A.
      ]. Variant forms of Ph translocations are seen in 5–10% of CML cases [
      • Sandberg A.A.
      ]. When CML progresses, additional chromosome aberrations are noted in 75–80% of the cases, the most common ones being trisomy 8, an additional Ph, an i(17q), trisomy 19, trisomy 21, and loss of a sex chromosome [
      • Sandberg A.A.
      ].
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Cancer Genetics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Rowley J.D.
        A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining.
        Nature. 1973; 243: 290-292
        • de Klein A.
        • Hagemeijer A.
        Cytogenetic and molecular analysis of the Ph translocation in chronic myeloid leukemia.
        Cancer Surv. 1984; 3: 515-529
        • Sandberg A.A.
        The Chromosomes in Human Cancer and Leukemia. ed 2. Elsevier Science, New York1990
        • Mitelman F.
        • Mertens F.
        • Johansson B.
        A breakpoint map of recurrent chromosomal rearrangements in human neoplasia.
        Nature Genet. 1997; 15: 417-474
        • Chen Z.
        • Notohamiprodjo M.
        • Richards P.D.
        • Lane F.B.
        • Morgan R.
        • Stone J.F.
        • Sandberg A.A.
        Some observations on fluorescence in situ hybridization evaluation of chronic myelocytic leukemia.
        Cancer Genet Cytogenet. 1997; 98: 1-3
      1. ISCN (1995): An International System for Human Cytogenetic Nomenclature. F. Mitelman, ed. S. Karger, Basel.