Abstract
12q13 abnormalities have been reported to be associated with a variety of benign and
malignant solid tumors. Recently, they have been shown to be a nonrandom karyotypic
change in acute myeloid leukemia. We report a case of de novo acute myeloid leukemia
with trilineage myelodysplasia showing t(12;17)(q13;q23) as the sole chromosomal abnormality.
A review of the literature indicates that 12q13 translocation in acute myeloid leukemia
is often associated with concomitant dysmyelopoietic changes. There is also evidence
to suggest that 12q13 translocation occurs more frequently in acute myeloid leukemia
with a prior history of mutagenic exposure or karyotypic indicators of secondary leukemia.
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Article info
Publication history
Accepted:
March 30,
1999
Received:
January 26,
1999
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
