Abstract
Although pituitary adenomas are among the most frequent intracranial neoplasms, only
very few have been cytogenetically analyzed. We have short-term cultured and karyotyped
28 consecutive pituitary adenomas (16 clinically nonfunctioning adenomas and 12 clinically
functioning adenomas), finding a normal karyotype in 22, whereas 6 had clonal chromosome
aberrations (5 nonfunctioning pituitary adenomas and 1 prolactinoma). The abnormal
karyotypes were relatively simple. Most anomalies were numerical, with a structural
rearrangement, t(6;19), being found in only one tumor. The most common aberrations
were trisomy 7 (3 adenomas), trisomy 9 (2 adenomas), trisomy 12 (2 adenomas), trisomy
20 (2 adenomas), and loss and gain in 2 separate clones of one X chromosome (2 adenomas).
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Article info
Publication history
Accepted:
March 30,
1999
Received:
November 9,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
