We investigated genetic anticipation of breast or ovarian cancer in patients with
familial breast cancer. Among 201 patients with breast cancer who had a family history
of breast or ovarian cancer, 95 families had affected familial members in the previous
generation. Of these families, 2 were excluded because of insufficient data. From
the 93 eligible families, 112 and 111 members were identified in the previous and
proband generations, respectively. BRCA mutations were detected in 26 (28.0%) of the 93 probands. The median age at diagnosis
of the first generation was 57 years and of the second generation was 40 years, which
was a significant difference. The result from the mixed-effects model also demonstrated
significant genetic anticipation (P < 0.0001). The expected age difference at onset of breast or ovarian cancer between
the two generations was 17.06 years. BRCA mutation status did not influence the generational difference in age at diagnosis
(17.99 vs. 16.62 y, P = 0.3973). Genetic counseling and early screening should be provided to women whose
parent had a breast or ovarian cancer diagnosis.
Keywords
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Article info
Publication history
Published online: April 11, 2014
Accepted:
April 1,
2014
Received in revised form:
April 1,
2014
Received:
July 17,
2013
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
