Despite the expanding role of genomic sequencing and other molecular techniques in
today's healthcare system, conventional cytogenetic analysis remains an important
tool in prenatal, constitutional, and oncology studies. The challenge remains in how
to engage new learners in chromosome identification and analysis. Our laboratory has
addressed this issue through the creation of an interactive software tool called Karyotyper.
This program, designed by an experienced cytotechnologist, utilizes a game-centric
approach to train users in cytogenetic analysis. Through a series of modules, the
learner is taught how to recognize and identify individual chromosomes. As the learner
progresses through the game modules, the feedback provided becomes less immediate.
Separate units have been created for different band levels of resolution, and a variety
of normal, aneuploid, and structurally abnormal cells have been included. In addition,
modules have been developed to assess competency of experienced technicians.
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