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Gamification of Chromosome Identification: Creation of a Software Tool to Introduce Cytogenetic Analysis

      Despite the expanding role of genomic sequencing and other molecular techniques in today's healthcare system, conventional cytogenetic analysis remains an important tool in prenatal, constitutional, and oncology studies. The challenge remains in how to engage new learners in chromosome identification and analysis. Our laboratory has addressed this issue through the creation of an interactive software tool called Karyotyper. This program, designed by an experienced cytotechnologist, utilizes a game-centric approach to train users in cytogenetic analysis. Through a series of modules, the learner is taught how to recognize and identify individual chromosomes. As the learner progresses through the game modules, the feedback provided becomes less immediate. Separate units have been created for different band levels of resolution, and a variety of normal, aneuploid, and structurally abnormal cells have been included. In addition, modules have been developed to assess competency of experienced technicians.
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