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Background: Urine cytology has a low sensitivity for diagnosis of high grade urothelial carcinoma.
Bladder cancer harbors frequent coding mutations in TP53, FGFR3, RAS, and PIK3CA,
in addition to TERT promoter mutations. The study evaluates the feasibility of a multiplexed-PCR
based Next Generation sequencing (NGS) assay on urine samples for diagnosis and monitoring
of bladder carcinoma.
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