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With clinical adoption of massively parallel sequencing into personalized cancer treatment,
a bottleneck occurs during clinical interpretation of the large amount of variants
seen in tumors, which requires curating an ever increasing pool of published studies.
While some groups approach this problem by housing variant interpretations behind
paywalls to support further curation, the Clinical Interpretations of Variants in
Cancer database (CIViC, www.civicdb.org) employs crowdsourced curation and expert
moderation within a fully open and free resource. Along with submitting new content,
the public can also comment on and suggest revisions to existing content in CIViC,
enabling rapid update of the resource in response to emerging research.
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