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Conventional cytogenetics are a diagnostic cornerstone for hematologic malignancies
but have changed little over the past 50 years. Newer whole genome sequencing (WGS)
methods can provide unbiased single-nucleotide resolution of all genomic variants.
We sought to determine the clinical utility of ChromoSeq, a high-coverage WGS-based
assay, compared to conventional cytogenetics in hematologic malignancies.
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