The crowd-sourced, public domain knowledgebase CIViC (Clinical Interpretations of
Variants in Cancer; civicdb.org) is composed of literature-derived evidence for the
clinical utility of cancer variants. Evidence is captured in CIViC using concepts
from established ontologies and CIViC-defined descriptive fields alongside human-readable
text. This structured data allows for complex searches, programmatic access, and rapid
integration into other resources. Anyone can curate evidence for CIViC by creating
a login. CIViC content is freely available without registration via the web interface,
text downloads or API access, and has been attributed to the public domain (CC0) declaration.
While content in any stage is always available, high-quality content is supported
by a gate-keeper model with labels clearly denoting expert-moderated content.
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© 2020 Published by Elsevier Inc.
