46. ClinGen somatic cancer working group: Enhancing standardized interpretation of cancer genetic data for clinical use

      The Clinical Genome (ClinGen) Resource, is a US National Human Genome Research Institute (NHGRI)-funded program to facilitate interpretation, annotation and utilization of clinical genomic data. ClinGen assembles experts to engage in standardized curation within clinical domains. Somatic Cancer is a ClinGen Clinical Domain Working Group (CDWG), consisting of >95 members worldwide with clinical (oncology, pathology) and genomics expertise. Somatic CDWG members identify cancer candidate genes that require expert curation to achieve consensus in clinical interpretation. The Somatic CDWG is currently creating Variant Curation Expert Panels (VCEPs) to perform standardized curation and clinical interpretation of somatic variants. The process is highly analogous to the FDA-recognized ClinGen germline VCEP process. Wherever necessary, VCEPs develop gene-disease specific modifications to address gaps in existing variant assessment guidelines such as the AMP/ASCO/CAP guidelines and minimum variant level data to report cancer somatic variants, published by the Somatic Cancer CDWG.
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