- •160 genes were aberrantly methylated in LUAD since stage I.
- •We evaluated LUAD-specific methylation diagnostic biomarkers and established a diagnostic model with superior sensitivity and specificity.
- •This model could distinguish between LUAD and LUSC.
- •The HOXA1 gene showed higher methylation levels in LUAD than in 10 other cancers.
- •HOXA1 may be a LUAD-specific diagnostic biomarker.
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