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First report of t(5;11) KMT2A-MAML1 fusion in de novo infant acute lymphoblastic leukemia

Published:September 21, 2020DOI:https://doi.org/10.1016/j.cancergen.2020.09.004

      Highlights

      • Novel translocation t(5;11)(q35;q23) detected in the context of de novo infant ALL.
      • RNA sequencing performed via our institutional childhood cancer sequencing (KiCS) program confirmed translocation t(5;11)(q35;q23) resulting in the formation of KMT2A-MAML1 gene fusion. The breakpoints were 11q23 and 5q35, wherein no KMT2A partner genes have been previously reported.
      • Patient continues to be in remission 22 months from diagnosis, but longer-term follow-up will be essential to determine prognostic significance.

      Abstract

      Infant acute lymphoblastic leukemia (ALL) comprises 2.5%–5% of pediatric ALL with inferior survival compared to older children. A majority of infants (80%) with ALL harbor KMT2A gene rearrangement, which portends a poor prognosis. Approximately 94 different partner genes have been identified to date. The common rearrangements include t(4;11)(q21;q23)KMT2A-AFF1,t(11;19) (q23;p13.3)KMT2A-MLLT1 and t(9;11)(p22;q23)KMT2A-MLLT3. We report a novel translocation t(5;11)(q35;q23)KMT2A-MAML1 in newly diagnosed infant precursor B-ALL. Long-term follow-up and a larger number of patients are needed to better understand its prognostic significance.

      Keywords

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