Highlights
- •Novel translocation t(5;11)(q35;q23) detected in the context of de novo infant ALL.
- •RNA sequencing performed via our institutional childhood cancer sequencing (KiCS) program confirmed translocation t(5;11)(q35;q23) resulting in the formation of KMT2A-MAML1 gene fusion. The breakpoints were 11q23 and 5q35, wherein no KMT2A partner genes have been previously reported.
- •Patient continues to be in remission 22 months from diagnosis, but longer-term follow-up will be essential to determine prognostic significance.
Abstract
Infant acute lymphoblastic leukemia (ALL) comprises 2.5%–5% of pediatric ALL with
inferior survival compared to older children. A majority of infants (80%) with ALL
harbor KMT2A gene rearrangement, which portends a poor prognosis. Approximately 94
different partner genes have been identified to date. The common rearrangements include
t(4;11)(q21;q23)KMT2A-AFF1,t(11;19) (q23;p13.3)KMT2A-MLLT1 and t(9;11)(p22;q23)KMT2A-MLLT3. We report a novel translocation t(5;11)(q35;q23)KMT2A-MAML1 in newly diagnosed infant precursor B-ALL. Long-term follow-up and a larger number
of patients are needed to better understand its prognostic significance.
Keywords
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Article Info
Publication History
Published online: September 21, 2020
Accepted:
September 20,
2020
Received in revised form:
September 16,
2020
Received:
April 3,
2020
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
