Highlights
- •Long-term follow up and clinicopathologic review of two pediatric patients following cardiac and intestine/liver allograft.
- •EBV-positive polymorphus post-transplant lymphoproliferative disorder (PTLD) with Trisomy 3.
- •Recurrent trisomy 3 in polymorphus PTLD in two pediatric patients.
Abstract
Trisomy 3 has been previously reported in association with T-cell lymphomas and less
commonly in different types of non-Hodgkin B-cell lymphomas. Trisomy 3 has also been
reported in two cases of pediatric post-transplant lymphoproliferative disorder (PTLD).
We present comprehensive clinicopathologic review of two pediatric patients with cardiac
and liver/intestinal allografts that developed polymorphic PTLD characterized by trisomy
3. Both patients had Epstein-Barr virus (EBV) viremia and EBV was positive in tissue
by EBER in situ hybridization. Using karyotype analysis and fluorescence in situ hybridization, we identified trisomy 3 in both patients. Both patients responded
to treatment and are now free of the PTLD. Trisomy 3, an uncommon cytogenetic finding
in pediatric polymorphic PTLD, may be a recurrent cytogenetic aberration if confirmed
in a larger study of pediatric PTLDs. Further clinical follow up might help stratify
significance of trisomy 3 as a prognostic factor.
Keywords
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Article Info
Publication History
Published online: October 02, 2020
Accepted:
September 28,
2020
Received in revised form:
August 6,
2020
Received:
May 13,
2020
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
