Abstract| Volume 264, SUPPLEMENT 1, 2, June 2022

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4. Current applications of cell-free DNA in pregnancy and oncology

      The earliest report of cell-free DNA in healthy individuals dates to the 1940s and it has been most widely adopted in medicine in assessing fetal risk of chromosomal abnormalities in pregnant women. In oncology, there are a variety of clinical applications for a minimally invasive blood test for cell-free DNA released from tumor cells. The increased adoption of targeted cancer therapies underscores the need to augment invasive tissue biopsies with alternative detection methods that rapidly monitor treatment response. In this lecture, I will review the clinical indications for cell-free DNA testing and discuss opportunities and challenges of cell-free DNA test validation in pregnancy and oncology.
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