Highlights
- •MUC16 gene is frequently mutated in GBM but not in LGG patients.
- •Mutated-MUC16 in LGG patients is associated with better prognosis.
- •MUC16 mutation in GBM patients is associated with worse prognosis.
- •MUC16 mutation may assist in glioma diagnosis and prognosis.
Abstract
MUC16 is a member of the attached mucin family that encodes cancer antigen 125 (CA-125),
but the association of MUC16 status with grade and subtypes of glioma patients has
not yet been established. Data for MUC16 mRNA expression in 37 different cancer types
were considered, and genomic data from the Cancer Genome Atlas (TCGA) from 1051 low-grade
glioma (LGG) patients and 833 glioblastoma (GBM) patients were analyzed. LGG and GBM
has low expression of MUC16, but it is frequently mutated in GBM. Kaplan-Meier survival
analysis, glioma subtypes, methylation, and isocitrate dehydrogenase (IDH1) status
were all performed. We found that mutated-MUC16 in LGG patients is associated with
better prognosis considering overall survival (OS), IDH1, methylation, 1p/19q, and
10q status. Conversely, MUC16 mutation were related with worse prognosis in GBM patients
upon analyzing those same parameters. Therefore, MUC16 mutations may assist in glioma
diagnosis and prognosis and should be further studied in this tumor type.
Keywords
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Article info
Publication history
Published online: November 19, 2022
Accepted:
November 16,
2022
Received in revised form:
October 21,
2022
Received:
July 14,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
