Highlights
- •The analysis identified kidney renal clear cell carcinoma (KIRC) as a cancer type most likely to be affected by cuproptosis.
- •This study analyzed the multi-omic data to explore the cancer-noncancer expression pattern and potential immune involvement of the cuproptosis pathway in KIRC.
- •This study clustered the TCGA KIRC samples based on the gene set of 12 cuproptosis genes to study the role of cuproptosis in the KIRC immune microenvironment and found the potential value of cuproptosis signature for immunotherapy prognosis.
- •This study concluded that cuproptosis might affect KIRC and had potential application value in immune therapy. We hope this study can contribute to the application of cuproptosis in the clinical therapy of KIRC.
Abstract
Cuproptosis is a newly identified programmed cell death pathway mediated by intracellular
free copper. Cuproptosis genes were studied in this study for a better insight into
the role of cuproptosis in cancers. The analysis identified kidney renal clear cell
carcinoma (KIRC) as a cancer type most likely to be affected by cuproptosis. This
study analyzed the multi-omic data to explore the cancer-noncancer expression pattern
and potential immune involvement of the cuproptosis pathway in KIRC. This study clustered
the TCGA KIRC samples based on the gene set of 12 cuproptosis genes to study the role
of cuproptosis in the KIRC immune microenvironment and found the potential value of
cuproptosis signature for immunotherapy prognosis. This study concluded that cuproptosis
might affect KIRC and had potential application value in immune therapy. Hopefully,
this study can contribute to the application of cuproptosis in the clinical therapy
of KIRC.
Keywords
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Article info
Publication history
Published online: March 14, 2023
Accepted:
March 10,
2023
Received in revised form:
March 9,
2023
Received:
February 14,
2023
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
