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Abstract
A patient who developed Philadelphia chromosome-positive chronic myelogenous leukemia
(CML) 5 years after successful treatment for thyroid carcinoma, is reported. The Philadelphia
chromosome was the typical 9;22 translocation. Southern blot analysis showed breakpoint
cluster region rearrangement as observed in classical CML. Up to now, only two cases
of CML have been reported following treatment for thyroid carcinoma. This rare complication
has also been described after therapy for other malignancies. At present, it is not
clear whether the development of CML after thyroid carcinoma represents a therapy-induced
complication, a coincidence, or an increased susceptibility to secondary malignancies
due to the malignant process itself.
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Article Info
Publication History
Accepted:
January 30,
1991
Received:
December 22,
1990
Footnotes
☆This work was supported by the Inter-University Network for Fundamental Research sponsored by the Belgian Government (1987–1991).
Identification
Copyright
© 1991 Published by Elsevier Inc.
